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・ Cyclidalis
・ Cyclidia
・ Cyclidia dictyaria
・ Cyclidia fabiolaria
・ Cyclidia fractifascia
・ Cyclidia javana
・ Cyclidia orciferaria
・ Cyclidia pitmani
・ Cyclidia rectificata
・ Cyclidia sericea
・ Cyclidia substigmaria
・ Cyclidia tetraspota
・ Cyclidiinae
・ Cyclin
・ Cyclin A
Cyclin A1
・ Cyclin A2
・ Cyclin B
・ Cyclin B1
・ Cyclin B2
・ Cyclin D
・ Cyclin D/Cdk4
・ Cyclin D1
・ Cyclin D2
・ Cyclin D3
・ Cyclin E
・ Cyclin E1
・ Cyclin E2
・ Cyclin H
・ Cyclin K


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Cyclin A1 : ウィキペディア英語版
Cyclin A1

Cyclin-A1 is a protein that in humans is encoded by the ''CCNA1'' gene.
== Function ==

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell division cycle. Cyclins function as activating subunits of enzymatic complex together with cyclin-dependent kinases (CDKs). Different cyclins exhibit distinct expression and degradation patterns that contribute to the temporal coordination of cell cycle events. Cyclin A1 was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of meiosis. This cyclin binds both Cdk1 and Cdk2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F1, and the Kip/Cip family of CDK-inhibitor proteins.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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